S1v3 crashes upon opening any of the Softube stuff, all but one of the Kush Audio plugins won't even show up in the DAW, the McDSP plugins crash the DAW, and VMR crashed my DAW as well the first time I opened it. For some reason S1 v3 is having trouble with a lot of the AudioUTOPIA plugins, no matter which plugin format.
I also own and use Studio One v3, running it on a Windows 10 64 bit system.
I own VMR legit (everything but bomber), and I use the VST3 version every day.